Vähärautio Lab
Exploring emerging resistance at single-cell resolution
About Us
We study cell-fate decisions: why does a cell survive a perturbation that kills many other cells?
We explore this in the context of high-grade serous ovarian cancer that typically becomes resistant to applied therapies after initial response.
We investigate the roles of somatic copy number aberrations, the tumor microenvironment, and various signalling pathways in both pre-existing resistant states and treatment-induced, potentially adaptive patterns.
Our Research
The Vähärautio Lab is a cancer biology research group based in Helsinki, Finland, that aims to unravel the mechanisms that tumor cells initially employ to escape the control of their environment and initiate malignant growth, as well as those they utilize later to survive drug treatments.
We are pursuing these mechanisms using single-cell transcriptomics, an approach that offers an unbiased way to study them at multiple levels: in individual cells, subpopulations, and tissues. Single-cell transcriptomics also enables us to analyze aberrations, whether readily detectable in cancer specimens or generated through genome editing, and their effects on transcriptional networks that define cellular states, on a scale sufficient to yield both biologically and clinically relevant information.
Join Us
Be part of the Vähärautio lab’s mission to unravel cancer’s mysteries.
Funding
